Article (Scientific journals)
The mh gene causing double-muscling in cattle maps to bovine chromosome 2
Charlier, Carole; Coppieters, Wouter; Farnir, Frédéric et al.
1995In Mammalian Genome, 6, p. 788-792
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Abstract :
[en] While the hereditary nature of the double-muscling phenotype (a generalized muscular hypertrophy documented in several cattle breeds) is well established, its precise segregation mode has remained controversial. Both monogenic models (autosomal dominant or recessive) and oligogenic models have been proposed. Using a panel of 213 bovine microsatellite markers, and an experimental pedigree obtained by backcrossing double-muscled (Belgian Blue)xconventional (Friesian) F1 dams to double-muscled sire, we have mapped a locus on bovine Chromosome (Chr) 2 that accounts for all the phenotypic variance in the backcross generation. This locus, referred to as mh (muscular hypertrophy), has been positioned with respect to a map composed of seven Chr 2-specific microsatellites, at 2 cM from the closest marker. This result confirms the validity in the Belgian Blue population of the monogenic model involving an autosomal mh locus, characterized by a wild-type + and a recessive mh allele, causing the double-muscling phenotype in the homozygous condition. The linkage relationship between the mh locus and the Chr 2 markers was confirmed in three informative pedigrees collected from the general Belgian Blue Cattle population, reinforcing the notion of genetic homogeneity of the double-muscling trait in this breed. This work paves the way towards marker-assisted selection for or against the double-muscling trait, and towards positional cloning of the corresponding gene.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Charlier, Carole  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Grobet, L.
Leroy, Pascal ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Michaux, C.
Mni, Myriam ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Schwers, A.
Vanmanshoven, P.
Hanset, R.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
The mh gene causing double-muscling in cattle maps to bovine chromosome 2
Publication date :
1995
Journal title :
Mammalian Genome
ISSN :
0938-8990
eISSN :
1432-1777
Publisher :
Springer Verlag, New York, United States - New York
Volume :
6
Pages :
788-792
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2010

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