Reference : The mh gene causing double-muscling in cattle maps to bovine chromosome 2
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/34388
The mh gene causing double-muscling in cattle maps to bovine chromosome 2
English
Charlier, Carole mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Grobet, L. [> >]
Leroy, Pascal mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Michaux, C. [> >]
Mni, Myriam mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Schwers, A. [> >]
Vanmanshoven, P. [> >]
Hanset, R. [> >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
1995
Mammalian Genome : Official Journal of the International Mammalian Genome Society
Springer Verlag
6
788-792
Yes (verified by ORBi)
International
0938-8990
1432-1777
New York
NY
[en] While the hereditary nature of the double-muscling phenotype (a generalized muscular hypertrophy documented in several cattle breeds) is well established, its precise segregation mode has remained controversial. Both monogenic models (autosomal dominant or recessive) and oligogenic models have been proposed. Using a panel of 213 bovine microsatellite markers, and an experimental pedigree obtained by backcrossing double-muscled (Belgian Blue)xconventional (Friesian) F1 dams to double-muscled sire, we have mapped a locus on bovine Chromosome (Chr) 2 that accounts for all the phenotypic variance in the backcross generation. This locus, referred to as mh (muscular hypertrophy), has been positioned with respect to a map composed of seven Chr 2-specific microsatellites, at 2 cM from the closest marker. This result confirms the validity in the Belgian Blue population of the monogenic model involving an autosomal mh locus, characterized by a wild-type + and a recessive mh allele, causing the double-muscling phenotype in the homozygous condition. The linkage relationship between the mh locus and the Chr 2 markers was confirmed in three informative pedigrees collected from the general Belgian Blue Cattle population, reinforcing the notion of genetic homogeneity of the double-muscling trait in this breed. This work paves the way towards marker-assisted selection for or against the double-muscling trait, and towards positional cloning of the corresponding gene.
Researchers ; Professionals
http://hdl.handle.net/2268/34388
10.1007/BF00539005

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