Article (Scientific journals)
2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Quetin-Leclercq, Joëlle; Dive, Georges; Delaude, Clément et al.
1994In Phytochemistry, 35 (2), p. 533-536
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Keywords :
conformational study; cytotoxic activity; 2D NMR spectra; 2,7-dihydroxyapogeissoschizine; indole alkaloid; Strychnos gossweileri
Abstract :
[en] In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests.
Disciplines :
Pharmacy, pharmacology & toxicology
Phytobiology (plant sciences, forestry, mycology...)
Author, co-author :
Quetin-Leclercq, Joëlle
Dive, Georges ;  Université de Liège - ULiège > Centre d'ingénierie des protéines
Delaude, Clément ;  Université de Liège - ULiège > Relations académiques et scientifiques (Sciences)
Warin, Roger 
Bassleer, Roger ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
2,7-dihydroapogeissoschizine from root bark of strychnos Gossweileri
Publication date :
1994
Journal title :
Phytochemistry
ISSN :
0031-9422
eISSN :
1873-3700
Publisher :
Pergamon Press, New York, United States - New York
Volume :
35
Issue :
2
Pages :
533-536
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 January 2010

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