Reference : Galanin Decreases the Activity of Locus Coeruleus Neurons in Vitro

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/2268/34051

Title :	Galanin Decreases the Activity of Locus Coeruleus Neurons in Vitro
Language :	English
Author, co-author :	Seutin, Vincent [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
	Verbanck, Paul [> > > >]
	Massotte, Laurent [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
	Dresse, Albert [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Publication date :	11-May-1989
Journal title :	European Journal of Pharmacology
Volume :	164
Issue/season :	2
Pages :	373-6
Audience :	International
ISSN :	0014-2999
Abstract :	[en] A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging from 20 to 100% at 10(-7) M. Experiments performed in low-Ca2+, high-Mg2+ medium also showed a significant inhibition by galanin (10(-7) M) in three out of five neurons, which suggests that the peptide acts directly.
Permalink :	http://hdl.handle.net/2268/34051

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