ORBi: Desaive Thomas - Study of ventricular interaction during pulmonary embolism using clinical identification in a minimum cardiovascular system model.

Reference : Study of ventricular interaction during pulmonary embolism using clinical identification...


	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/2268/33839

Title :	Study of ventricular interaction during pulmonary embolism using clinical identification in a minimum cardiovascular system model.
Language :	English
Author, co-author :	Desaive, Thomas [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles - Département d'astrophys., géophysique et océanographie (AGO) >]
	Ghuysen, Alexandre [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière >]
	Lambermont, Bernard [Université de Liège - ULg > > Frais communs médecine >]
	Kolh, Philippe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
	Dauby, Pierre [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles >]
	Starfinger, C. [> > > >]
	Hann, C. E. [> > > >]
	Chase, J. G. [> > > >]
	Shaw, G. M. [> > > >]
Publication date :	2007
Journal title :	Proceedings of the IEEE
Publisher :	IEEE
Pages :	2976-9
On invitation :	No
Audience :	International
ISSN :	1557-170X
Event name :	29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Event date :	du 23 au 26 août 2007
Event place (city) :	Lyon
Event country :	France
Keywords :	[en] Animals ; Blood Flow Velocity ; Blood Pressure ; Cardiac Output ; Computer Simulation ; Heart Ventricles/physiopathology ; Models, Cardiovascular ; Pulmonary Artery/physiopathology ; Pulmonary Embolism/physiopathology ; Stroke Volume ; Swine
Abstract :	[en] Cardiovascular disturbances are difficult to diagnose and treat because of the large range of possible underlying dysfunctions combined with regulatory reflex mechanisms that can result in conflicting clinical data. Thus, medical professionals often rely on experience and intuition to optimize hemodynamics in the critically ill. This paper combines an existing minimal cardiovascular system model with an extended integral based parameter identification method to track the evolution of induced pulmonary embolism in porcine data. The model accounts for ventricular interaction dynamics and is shown to predict an increase in the right ventricle expansion index and a decrease in septum volume consistent with known physiological response to pulmonary embolism. The full range of hemodynamic responses was captured with mean prediction errors of 4.1% in the pressures and 3.1% in the volumes for 6 sets of clinical data. Pulmonary resistance increased significantly with the onset of embolism in all cases, as expected, with the percentage increase ranging from 89.98% to 261.44% of the initial state. These results are an important first step towards model-based cardiac diagnosis in the Intensive Care Unit.
Permalink :	http://hdl.handle.net/2268/33839
DOI :	10.1109/IEMBS.2007.4352954

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