Article (Scientific journals)
Common Prevalence Of Alanine And Glycine In Mobile Reactive Center Loops Of Serpins And Viral Fusion Peptides - Do Prions Possess A Fusion Peptide
Callebaut, I.; Tasso, A.; Brasseur, Robert et al.
1994In Journal of Computer-Aided Molecular Design, 8 (2), p. 175-191
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Abstract :
[en] Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by high levels of glycine. These two small residues, which are not simultaneously abundant in stable helices (standard or transmembrane), probably play an important role in mobility. Threonine and valine (also relatively small amino acids) are also abundant in these two kinds of peptides. Moreover, the known 3D structures of an uncleaved serpin reactive centre and a fusion peptide are strikingly similar. Such sequences possess many small residues and are found in several signal peptides and in PrP, a protein associated with spongiform encephalopathies and resembling virus envelope proteins. These properties may be related to the infection mechanisms of these diseases.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Callebaut, I.
Tasso, A.
Brasseur, Robert ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Portetelle, Daniel ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Mornon, Jp.
Language :
English
Title :
Common Prevalence Of Alanine And Glycine In Mobile Reactive Center Loops Of Serpins And Viral Fusion Peptides - Do Prions Possess A Fusion Peptide
Publication date :
1994
Journal title :
Journal of Computer-Aided Molecular Design
ISSN :
0920-654X
eISSN :
1573-4951
Publisher :
Kluwer Academic Publishers, Netherlands
Volume :
8
Issue :
2
Pages :
175-191
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 December 2009

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