ORBi: Guéders Maud - Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production

Reference : Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronch...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Anatomy (cytology, histology, embryology...) & physiology
	To cite this reference:	http://hdl.handle.net/2268/33353

Title :	Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production
Language :	English
Author, co-author :	Guéders, Maud [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Paulissen, Geneviève [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Crahay, Céline [ > > ]
	Quesada Calvo, Florence [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
	Hacha, Jonathan [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Van Hove, C. [ > > ]
	Tournoy, K. [ > > ]
	Louis, Renaud [Université de Liège - ULg > Département des sciences cliniques > Pneumologie - Allergologie >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Cataldo, Didier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
Publication date :	2009
Journal title :	Inflammation Research
Publisher :	Springer Science & Business Media B.V.
Volume :	58
Issue/season :	12
Pages :	845-54
Audience :	International
ISSN :	1023-3830
e-ISSN :	1420-908X
City :	Basel
Country :	Switzerland
Keywords :	[en] Animal models ; Asthma ; Cytokines ; Chemokines ; Inflammation
Abstract :	[en] Objective Animal models of asthma mimic major features of human disease. Since the genetic background of experimental animals might affect hyperresponsiveness and inflammation, we studied its potential influence and the mechanisms leading to differences in strains. Methods We applied a mouse model of allergic asthma to BALB/c and C57BL/6 mice. Results BALB/c mice displayed greater levels of airway reactivity to methacholine than C57BL/6 mice. Moreover, BALB/c mice exhibited higher numbers of mast cells in lung tissue when compared to C57BL/6. On the contrary, eosinophil and neutrophil counts in bronchoalveolar lavage fluid (BALF) as well as peribronchial eosinophilia were greater in C57BL/6. IL (Interleukin)-4, IL-5, IL-13, and CCL11 levels measured in whole-lung extracts were higher in BALB/c, while, in sharp contrast, CCL11 and CCL5 levels were higher in BALF of C57BL/6 mice. Conclusions We observed phenotypic differences between C57BL/6 and BALB/c mice in an asthma model with different distributions of pro-inflammatory cytokines and inflammatory cells.
Permalink :	http://hdl.handle.net/2268/33353
DOI :	10.1007/s00011-009-0054-2

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