ORBi: Swinnen J. V. - Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.

Reference : Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the m...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/33217

Title :	Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.
Language :	English
Author, co-author :	Swinnen, J. V. [ > > ]
	Beckers, A. [ > > ]
	Brusselmans, K. [ > > ]
	Organe, S. [ > > ]
	Segers, J. [ > > ]
	Timmermans, L. [ > > ]
	Vanderhoydonc, F. [ > > ]
	Deboel, L. [ > > ]
	Derua, R. [ > > ]
	Waelkens, E. [ > > ]
	De Schrijver, E. [ > > ]
	Van de Sande, T. [ > > ]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Foufelle, F. [ > > ]
	Verhoeven, G. [ > > ]
Publication date :	2005
Journal title :	Cancer Research
Publisher :	American Association for Cancer Research, Inc. (AACR)
Volume :	65
Issue/season :	6
Pages :	2441-8
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0008-5472
e-ISSN :	1538-7445
City :	Baltimore
Country :	MD
Keywords :	[en] AICA ; anabolism ; AMPK ; energy ; cancer
Abstract :	[en] Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an AMP analogue, mimicking a low energy status of the cell. Treatment of cancer cells with AICA riboside impeded lipogenesis, decreased protein translation, and blocked DNA synthesis. Cells treated with AICA riboside stopped proliferating and lost their invasive properties and their ability to form colonies. When administered in vivo, AICA riboside attenuated the growth of MDA-MB-231 tumors in nude mice. These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy.
Permalink :	http://hdl.handle.net/2268/33217

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Swinnen JV Cancer Res 2005.pdf		Publisher postprint	587.17 kB	Request copy
Open access	Swinnen J Cancer Res 2005.pdf		Author postprint	375.38 kB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5