Reference : When thoughts become action: An fMRI paradigm to study volitional brain activity in non-...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Social & behavioral sciences, psychology : Neurosciences & behavior
When thoughts become action: An fMRI paradigm to study volitional brain activity in non-communicative brain injured patients
Boly, Mélanie mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron - Comagroup > Neurologie > > >]
Coleman, M. R. [University of Cambridge > > > > > >]
Davis, M. H. [MRC Cognition and Brain Sciences Unit, > > > > > >]
Hampshire, A. [MRC Cognition and Brain Sciences Unit, > > > > > >]
Bor, D. [MRC Cognition and Brain Sciences Unit, > > > > > >]
Moonen, Gustave [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron - Département des sciences cliniques >]
Pickard, J. D. [> > > >]
Laureys, Steven mailto [Université de Liège - ULg > Centre de recherches du cyclotron - Comagroup > > >]
Owen, A. M. [> > > >]
Academic Press Inc Elsevier Science
Yes (verified by ORBi)
San Diego
[en] The assessment of voluntary behavior in non-communicative brain injured patients is often challenging due to the existence of profound motor impairment. In the absence of a full understanding of the neural correlates of consciousness, even a normal activation in response to passive sensory stimulation cannot be considered as proof of the presence of awareness in these patients. In contrast, predicted activation in response to the instruction to perform a mental imagery task would provide evidence of voluntary task-dependent brain activity, and hence of consciousness, in non-communicative patients. However, no data yet exist to indicate which imagery instructions would yield reliable single subject activation. The aim of the present study was to establish such a paradigm in healthy volunteers. Two exploratory experiments evaluated the reproducibility of individual brain activation elicited by four distinct mental imagery tasks. The two most robust mental imagery tasks were found to be spatial navigation and motor imagery. In a third experiment, where these two tasks were directly compared, differentiation of each task from one another and from rest periods was assessed blindly using a priori criteria and was correct for every volunteer. The spatial navigation and motor imagery tasks described here permit the identification of volitional brain activation at the single subject level, without a motor response. Volunteer as well as patient data [Owen, A. M., Coleman, M.R., Boly, M., Davis, M.H., Laureys, S., Pickard J.D., 2006. Detecting awareness in the vegetative state. Science 313, 1402] strongly suggest that this' paradigm may provide a method for assessing the presence of volitional brain activity, and thus of consciousness, in non-communicative brain-injured patients. (c) 2007 Elsevier Inc. All rights reserved.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS

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