Article (Scientific journals)
Uncoupling protein and alternative oxidase of Dictyostelium discoideum: occurrence, properties and protein expression during vegetative life and starvation-induced early development.
Jarmusszkiewicz, W.; Behrendt, M.; Navet, R. et al.
2002In FEBS Letters, 532, p. 459-464
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Keywords :
Mitochondrion; alternative oxidase; uncoupling protein; development; dictyostelium discoideum
Abstract :
[en] In this study we show that mitochondria of Dictyostelium discoideum contain both alternative oxidase (AOX) and uncoupling protein (UCP). AOX was stimulated by purine mononucleoside and was monomeric. UCP was stimulated by free fatty acids and was poorly sensitive to GTP. Both proteins collaborated in energy dissipation when activated together. AOX expression in free-living ameboid cells decreased strongly from exponential to stationary phase of growth but much less during starvation-induced aggregation. In contrast, UCP expression was constant in all conditions indicating permanent need. Our results suggest that AOX could play a role in cell differentiation, mainly by protecting prespore cells from programmed cell death.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Jarmusszkiewicz, W.
Behrendt, M.
Navet, R.
Sluse, Francis ;  Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire
Language :
English
Title :
Uncoupling protein and alternative oxidase of Dictyostelium discoideum: occurrence, properties and protein expression during vegetative life and starvation-induced early development.
Publication date :
2002
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
532
Pages :
459-464
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 December 2009

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