Reference : Detecting consciousness in a total Locked-in syndrome: an active event related paradigm
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/32997
Detecting consciousness in a total Locked-in syndrome: an active event related paradigm
English
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Perrin, Fabien [> >]
Schabus, Manuel [> >]
Hustinx, Roland mailto [Université de Liège - ULg > > Médecine nucléaire >]
Majerus, Steve mailto [Université de Liège - ULg > Département des sciences cognitives > Psychopathologie cognitive >]
Moonen, Gustave mailto [Université de Liège - ULg > > Neurologie Sart Tilman >]
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Bruno, Marie-Aurélie mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Laureys, Steven mailto [Université de Liège - ULg > > Neurologie Sart Tilman >]
2009
Neurocase : Case Studies in Neuropsychology, Neuropsychiatry & Behavioural Neurology
Psychology Press (UK)
25
1-7
Yes (verified by ORBi)
International
1355-4794
1465-3656
Lisse
The Netherlands
[en] Locked-in syndrome ; Consciousness ; Brain injury ; Evoked potentials ; Tetraplegia
[en] Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. In this study, consciousness was detected in a 21-year-old woman who presented a total locked-in syndrome after a basilar artery thrombosis (49 days post-injury) using an active event-related paradigm. The patient was presented sequences of names containing the patient's own name and other names. The patient was instructed to count her own name or to count another target name. Similar to 4 age- and gender-matched healthy controls, the P3 response recorded for the voluntarily counted own name was larger than while passively listening. This P3 response was observed 14 days before the first behavioral signs of consciousness. This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; French Speaking Community of Belgium Concerted Research Action ; J.S. McDonnell Foundation ; European Commission ; Mind Science Foundation
http://hdl.handle.net/2268/32997
10.1080/13554790902724904
http://www.coma.ulg.ac.be/papers/locked-in_syndrome.html

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