Reference : Interet des expectorations induites dans l'exploration de l'asthme.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/32958
Interet des expectorations induites dans l'exploration de l'asthme.
French
[en] Value of induced sputum in the investigation of asthma
Louis, Renaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Bettiol, Jane [> > > >]
Cataldo, Didier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
Bureau, Fabrice [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Seumois, G. [> > > >]
Radermecker, Maurice [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Bartsch, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Djukanovic, R. [> > > >]
2003
Revue des Maladies Respiratoires
Masson
20
2 Pt 1
215-23
Yes (verified by ORBi)
International
0761-8425
Moulineaux Cedex 9
France
[en] Asthma/classification/diagnosis/drug therapy/immunology ; Biological Markers/analysis ; Cost-Benefit Analysis ; Eosinophils/immunology ; Humans ; Inflammation ; Leukocyte Count ; Reproducibility of Results ; Saline Solution, Hypertonic/diagnostic use ; Severity of Illness Index ; Specimen Handling/economics/methods/standards ; Sputum/chemistry/cytology/immunology
[en] INTRODUCTION: The technique of induced expectoration generates sputum by the inhalation of hypertonic saline. On account of its non-invasive character, its simplicity, its relative harmlessness, its cost effectiveness and its reproducibility this technique, that appeared in the early 1990's, has rapidly established itself as the technique of choice in the investigation of bronchial inflammation in asthma. STATE OF THE ART: We present the results of our studies that have contributed to the validation of the technique at the methodological level and to the exploitation of the cellular contents as much as the fluid phase of the expectorations in characterising bronchial inflammation in asthmatics. Our results confirm an infiltration of the airways of asthmatics with eosinophils that appears to be proportional to the severity of the illness. We evaluate the effect of inhaled steroids and of theophylline on sputum eosinophilia and bronchial reactivity and discuss the role of eosinophils on bronchial hyperreactivity. Finally we discuss the use of induced expectoration in clinical practice in asthma. PERSPECTIVES: The analysis of induced sputum could well become a valuable tool in the clinical evaluation and monitoring of asthma in the same way as symptoms and abnormalities of lung function. CONCLUSIONS: Induced expectoration has certainly contributed to the understanding of the cellular and molecular mechanisms of asthma as well as the role of bronchial inflammation in the clinical manifestations of the disease.
Researchers ; Professionals
http://hdl.handle.net/2268/32958
also: http://hdl.handle.net/2268/8116 ; http://hdl.handle.net/2268/15428
RMR-04-2003-20-2-0761-8425-101019-ART10
http://www.em-consulte.com/revue/rmr/20/2

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