mass spectrometry; DNA; telomestatin; quadruplex; duplex; kinetics
Abstract :
[en] Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to the G-quadruplex delays the unwinding of the quadruplex structure and formation of the duplex.
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
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