Article (Scientific journals)
Consequences of Cold and Warm Ischemia on Pulmonary Mitochondrial Respiratory Function
Detry, Olivier; Willet, K.; Lambermont, Bernard et al.
1997In Transplantation Proceedings, 29 (5), p. 2338-9
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Keywords :
Cold and warm ischemia; pulmonary mitochodria; respiratory function
Abstract :
[en] IN RECENT years, pulmonary transplantation has become the treatment of choice for several end-stage lung diseases, but remains limited by the scarcity of suitable donors and the lack of reliable prolonged method of lung preservation.1 Transplantation of lung 6 hours postharvest leads to an increased incidence of primary graft dysfunction, due in part to ischemic damage of pulmonary cell structure and metabolism, and to acute reperfusion injury. However, very little is known about the real mechanisms of pulmonary cell injuries before, during, and after lung transplantation. <br /> <br />During ischemia, the cytosolic and mitochondrial adenine nucleotide content falls,2,3 phospholipids are degraded, membrane permeabilities are increased, and the cytosolic levels of Na+, Ca2+ and phosphate are raised.4 Thus, cold and warm ischemia may induce cell dysfunctions and irreversible injuries responsible for necrosis. As mitochondia are believed to be the site of the determinants of irreversibility,5 the study of permanent oxidative phosphorylation damage after ischemia should be of great interest. <br /> <br />The aim of this present study was to investigate the consequences of warm and cold ischemia on the oxidative phosphorylation of isolated lung mitochondria
Disciplines :
Biochemistry, biophysics & molecular biology
Cardiovascular & respiratory systems
Surgery
Author, co-author :
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Willet, K.
Lambermont, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Degotte, M.
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie générale
Meurisse, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Limet, Raymond ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Sluse, Francis ;  Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire
Language :
English
Title :
Consequences of Cold and Warm Ischemia on Pulmonary Mitochondrial Respiratory Function
Publication date :
August 1997
Journal title :
Transplantation Proceedings
ISSN :
0041-1345
eISSN :
1873-2623
Publisher :
Elsevier Science, New York, United States - New York
Volume :
29
Issue :
5
Pages :
2338-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 February 2009

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