Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae.

[en] The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be divided into 27 subfamilies including ADP/ATP, phosphate and citrate carriers, putative oxoglutarate and GDC carriers and 22 new subfamilies. Topology predictions using the 'positive inside rule' approach have shown that the yeast carriers are similarly oriented with both extremities exposed to the cytosol. In each subfamily, a strict conservation of the charged residues in the six transmembrane alpha-helices is observed, suggesting a functional role for these residues and the existence of 27 functionally distinct carriers.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Elmoualij, Benaïssa ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Duyckaerts, Claire ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)

Lamotte-Brasseur, Josette ; Université de Liège - ULiège > Unité de cristallographie

Sluse, Francis ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie

Language :

English

Title :

Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae.

Publication date :

1997

Journal title :

Yeast

ISSN :

0749-503X

eISSN :

1097-0061

Publisher :

Wiley, Chichester, United Kingdom

Volume :

Issue :

Pages :

573-581

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 December 2009

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