Article (Scientific journals)
Anticorps monoclonaux a usage therapeutique en hemato-oncologie. Generalites.
Gennigens, Christine; Collignon, Joëlle; Jerusalem, Guy et al.
2009In Revue Médicale de Liège, 64 (5-6), p. 264-7
Peer reviewed
 

Files


Full Text
Gennigens atc monoclon generalités[1].pdf
Publisher postprint (316.63 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/therapeutic use; Hematologic Neoplasms/drug therapy; Humans
Abstract :
[en] For many years, chemotherapy, hormonotherapy and immunotherapy were the mainstay of cancer treatment. Recent advances in our knowledge of cell biology and particularly of cancer cell transformation, growth and metastasis have led to the identification of specific pathways playing a role in the pathophysiology of cancer. New drugs specifically developed to control these targets are collectively named "targeted therapies". Two types of targeted therapies are available: kinase (mainly tyrosine kinase) inhibitors (suffix -nib) are small molecules binding directly to the intracellular kinase domain and acting as competitive inhibitor of ATP binding and monoclonal antibodies (suffix -mab) directed towards specific cell surface receptors or their ligands to prevent receptor activation. This paper will only review monoclonal antibodies (mabs). Thirty years after their discovery mAbs have become efficient therapeutic tools. Progress in molecular engineering as well as improved knowledge of cell signalling pathways together with a better selection of the targets turned them into valuable treatments. Several mAbs are currently licensed for the treatment of hematological or solid malignancies and many others are expected in the near future.
Disciplines :
Oncology
Author, co-author :
Gennigens, Christine  ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Collignon, Joëlle  ;  Université de Liège - ULiège > Oncologie médicale
Jerusalem, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Rorive, Andrée ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Sautois, Brieuc  ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Language :
French
Title :
Anticorps monoclonaux a usage therapeutique en hemato-oncologie. Generalites.
Alternative titles :
[en] Therapeutic monoclonal antibodies in hemato-oncology
Publication date :
2009
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
64
Issue :
5-6
Pages :
264-7
Peer reviewed :
Peer reviewed
Available on ORBi :
since 19 February 2010

Statistics


Number of views
387 (9 by ULiège)
Number of downloads
1774 (10 by ULiège)

Bibliography


Similar publications



Contact ORBi