Reference : Gene activation therapy: from the BLV model to HAM/TSP patients.
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Oncology
http://hdl.handle.net/2268/32563
Gene activation therapy: from the BLV model to HAM/TSP patients.
English
Lezin, Agnes [> > > >]
Olindo, Stephane [> > > >]
Belrose, Gildas [> > > >]
Signate, Aissatou [> > > >]
Cesaire, Raymond [> > > >]
Smadja, Didier [> > > >]
Macallan, Derek [> > > >]
Asquith, Becca [> > > >]
Bangham, Charles [> > > >]
Bouzar, Amel [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Gillet, Nicolas mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Defoiche, Julien [> > > >]
Florins, ARNAUD-FRANCOIS [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Verlaeten, Olivier [> > > >]
Burny, Arsene [> > > >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research - Gembloux Agro-Bio Tech >]
2009
Frontiers in Bioscience (Scholar Edition)
1
205-15
Yes (verified by ORBi)
International
1945-0516
1945-0524
NY
[en] Animals ; Gene Expression ; Genetic Therapy ; Humans ; Leukemia Virus, Bovine/genetics/physiology ; Models, Biological ; Paraparesis, Tropical Spastic/genetics/therapy ; Sheep
[en] HTLV-1 (human T-lymphotropic virus type 1) and BLV (bovine leukemia virus) are two related retroviruses infecting CD4+ and B lymphocytes in humans and ruminants, respectively. During infection, the host-pathogen interplay is characterized by very dynamic kinetics resulting in equilibrium between the virus, which attempts to proliferate, and the immune response, which seeks to exert tight control of the virus. A major determinant of disease induction by both viruses is the accumulation of provirus in peripheral blood. In the absence of viral proteins, virus infected cells escape recognition and destruction by the host immune response. We propose a novel therapeutic strategy based on transient activation of viral expression using epigenetic modulators; this exposes infected cells to the immune response and results in significant reductions in proviral loads. In the absence of satisfactory therapies, this viral gene-activation strategy might delay progression, or even be curative, for HTLV-1 induced myelopathy / tropical spastic paraparesis (HAM/TSP).
http://hdl.handle.net/2268/32563
also: http://hdl.handle.net/2268/138808

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