[en] Photodynamic therapy (PDT) is a treatment for cancer and for certain benign conditions that is based on the use of a photosensitizer and light to produce reactive oxygen species in cells. Many of the photosensitizers currently used in PDT localize in different cell compartments such as mitochondria, lysosomes, endoplasmic reticulum and generate cell death by triggering necrosis and/or apoptosis. Efficient cell death is observed when light, oxygen and the photosensitizer are not limiting ("high dose PDT"). When one of these components is limiting ("low dose PDT"), most of the cells do not immediately undergo apoptosis or necrosis but are growth arrested with several transduction pathways activated. This commentary will review the mechanism of apoptosis and growth arrest mediated by two important PDT agents. i.e. pyropheophorbide and hypericin. (C) 2003 Elsevier Inc. All rights reserved.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Volanti, Cédric ; Université de Liège - ULiège > Département des Sciences de la vie > Virologie et Immunologie
Vantieghem, Annelies; Katholieke Universiteit Leuven - KUL > Division of Bichemistry
Matroule, Jean-Yves; Université de Liège - ULiège > Département des Sciences de la Vie > Virologie et immunologie
Habraken, Yvette ; Université de Liège - ULiège > Département des Sicences de la vie > Virologie - Immunologie
Agostinis, Patricia; Katholieke Universiteit Leuven - KUL > Department of Molecular Cell Biology > Laboratory for Pharmaceutical Biology
Language :
English
Title :
Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers
Publication date :
15 October 2003
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
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