Reference : On the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/325
On the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
English
Gabelica, Valérie mailto [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
Galic, Nives [Université de Liège - ULg > > Chimie Physique, Spectrométrie de Masse > >]
De Pauw, Edwin mailto [Université de Liège - ULg > > Chimie physique, spectrométrie de masse >]
2002
Journal of the American Society for Mass Spectrometry
Elsevier Science
13
8
946-953
Yes (verified by ORBi)
International
1044-0305
New York
NY
[en] mass spectrometry ; cyclodextrin ; noncovalent interactions
[en] alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant that increases with the diacid chain length. However, the electrospray mass spectrometry (ES-MS) spectra showed that the relative intensity of the complex did not vary significantly with chain length. This contradiction is caused by a contribution of nonspecific adducts to the signal of the complex in ES-MS. In order to estimate the contribution of nonspecific adducts to the total intensity of the complexes with alpha-cyclodextrin, the comparison was made between alpha-cyclodextrin and maltohexaose, the latter being incapable of making inclusion complexes in solution. The signal observed for complexes between diacids and maltohexaose can only result from nonspecific electrostatic aggregation, and is found to be more favorable with the shorter diacids. This is also supported by MS/MS experiments. A procedure is described which allows estimation of the contribution of the nonspecific complex in the spectra of the complexes with alpha-cyclodextrin by using the relative intensity of the complex with maltohexaose. The contribution of the specific complex to the total signal intensity is found to increase with the diacid chain length, which is in agreement with solution behavior.
Centre Interfacultaire d'Analyse des Résidus en Traces - CART
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/325
10.1016/S1044-0305(02)00416-6
This is a postprint version of an article published in J Am Soc Mass Spectrom © 2002 Elsevier Science B.V.

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