Article (Scientific journals)
On the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
Gabelica, Valérie; Galic, Nives; De Pauw, Edwin
2002In Journal of the American Society for Mass Spectrometry, 13 (8), p. 946-953
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This is a preprint of an article published in J. Am. Soc. Mass Spectrom. © 2002 American Society for Mass Spectrometry. Published by Elsevier Science Inc.
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Keywords :
mass spectrometry; cyclodextrin; noncovalent interactions
Abstract :
[en] alpha-cyclodextrin complexes with linear alpha,omega-dicarboxylic acids were investigated by electrospray mass spectrometry. These hydrophobic complexes are known to have an equilibrium binding constant that increases with the diacid chain length. However, the electrospray mass spectrometry (ES-MS) spectra showed that the relative intensity of the complex did not vary significantly with chain length. This contradiction is caused by a contribution of nonspecific adducts to the signal of the complex in ES-MS. In order to estimate the contribution of nonspecific adducts to the total intensity of the complexes with alpha-cyclodextrin, the comparison was made between alpha-cyclodextrin and maltohexaose, the latter being incapable of making inclusion complexes in solution. The signal observed for complexes between diacids and maltohexaose can only result from nonspecific electrostatic aggregation, and is found to be more favorable with the shorter diacids. This is also supported by MS/MS experiments. A procedure is described which allows estimation of the contribution of the nonspecific complex in the spectra of the complexes with alpha-cyclodextrin by using the relative intensity of the complex with maltohexaose. The contribution of the specific complex to the total signal intensity is found to increase with the diacid chain length, which is in agreement with solution behavior.
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Chemistry
Author, co-author :
Gabelica, Valérie ;  Université de Liège - ULiège > Chimie physique, spectrométrie de masse
Galic, Nives;  Université de Liège - ULiège > Chimie Physique, Spectrométrie de Masse
De Pauw, Edwin  ;  Université de Liège - ULiège > Chimie physique, spectrométrie de masse
Language :
English
Title :
On the specificity of cyclodextrin complexes detected by electrospray mass spectrometry
Publication date :
2002
Journal title :
Journal of the American Society for Mass Spectrometry
ISSN :
1044-0305
eISSN :
1879-1123
Publisher :
Elsevier Science, New York, United States - New York
Volume :
13
Issue :
8
Pages :
946-953
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
This is a postprint version of an article published in J Am Soc Mass Spectrom © 2002 Elsevier Science B.V.
Available on ORBi :
since 21 July 2008

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