Reference : Subcellular Localization Of The Bovine Leukemia Virus R3 And G4 Accessory Proteins
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/32460
Subcellular Localization Of The Bovine Leukemia Virus R3 And G4 Accessory Proteins
English
Lefebvre, Laurent [> > > >]
Ciminale, Vincenzo [> > > >]
Vanderplasschen, Alain mailto [Université de Liège > > Immunologie et vaccinologie >]
D'Agostino, Donna [> > > >]
Burny, Arsène [> > > >]
Willems, Luc mailto [Université de Liège > > GIGA-Research >]
Kettmann, Richard [Université de Liège > > Gembloux Agro-Bio Tech >]
2002
Journal of Virology
Amer Soc Microbiology
76
15
7843-7854
Yes (verified by ORBi)
International
0022-538X
Washington
[en] Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for at least four proteins: Tax and Rex, which are involved in transcriptional and posttranscriptional regulation, respectively, and the accessory proteins R3 and G4 (for BLV) and p12(I), p13(II), and p30(II) (for HTLV-1). The present study was aimed at characterizing the subcellular localization of BLV R3 and G4. The results of immunofluorescence experiments on transfected HeLa Tat cells demonstrated that R3 is located in the nucleus and in cellular membranes, as previously reported for HTLV-1 p12(1). In contrast, G4, like p13(II), is localized both in the nucleus and in mitochondria. In addition, we have shown that G4 harbors a mitochondrial targeting signal consisting of a hydrophobic region and an amphipathic alpha-helix. Thus, despite a lack of significant primary sequence homology, R3 and p12(1) and G4 and p13(II) exhibit similar targeting properties, suggesting possible overlap in their functional properties.
Researchers ; Professionals
http://hdl.handle.net/2268/32460
also: http://hdl.handle.net/2268/29160
10.1128/JVI.76.15.7843-7854.2002

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
0042.pdfPublisher postprint4.17 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.