Reference : Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia vir...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Human health sciences : Oncology
http://hdl.handle.net/2268/10578
Spleen-dependent turnover of CD11b peripheral blood B lymphocytes in bovine leukemia virus-infected sheep.
English
Florins, Arnaud-Francois [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Gillet, Nicolas mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Asquith, Becca [> > > >]
Debacq, Christophe [> > > >]
Jean, Geneviève mailto [Université de Liège - ULg > Sciences agronomiques > Zootechnie >]
Schwartz-Cornil, Isabelle [> > > >]
Bonneau, Michel [> > > >]
Burny, Arsene [> > > >]
Reichert, Michal [> > > >]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Biologie cell. et moléc. >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research >]
2006
Journal of virology
80
24
11998-2008
Yes
International
0022-538X
1098-5514
United States
[en] Animals ; Antigens, CD11b/immunology ; Apoptosis/immunology ; B-Lymphocytes/immunology ; Cell Proliferation ; DNA Primers ; Deltaretrovirus Infections/immunology ; Fluoresceins ; Homeostasis/immunology ; Immunophenotyping ; Kinetics ; Leukemia Virus, Bovine/immunology ; Sheep ; Spleen/immunology ; Splenectomy ; Succinimides
[en] Lymphocyte homeostasis is determined by a critical balance between cell proliferation and death, an equilibrium which is deregulated in bovine leukemia virus (BLV)-infected sheep. We have previously shown that an excess of proliferation occurs in lymphoid tissues and that the peripheral blood population is prone to increased cell death. To further understand the mechanisms involved, we evaluated the physiological role of the spleen in this accelerated turnover. To this end, B lymphocytes were labeled in vivo using a fluorescent marker (carboxyfluorescein diacetate succinimidyl ester), and the cell kinetic parameters (proliferation and death rates) of animals before and after splenectomy were compared. We show that the enhanced cell death observed in BLV-infected sheep is abrogated after splenectomy, revealing a key role of the spleen in B-lymphocyte dynamics.
http://hdl.handle.net/2268/10578
also: http://hdl.handle.net/2268/138850 ; http://hdl.handle.net/2268/32297
10.1128/JVI.01447-06

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