Article (Scientific journals)
Viral glycoproteins in herpesviridae granulomas
Nikkels, Arjen; Debrus, S.; Delvenne, Philippe et al.
1994In American Journal of Dermatopathology, 16 (6), p. 588-592
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Keywords :
Varicella zoster virus; Herpes simplex virus; Granuloma; Immunohistochemistry; In situ hybridization
Abstract :
[en] Granulomatous reactions after varicella zoster virus (VZV) and herpes simplex virus (HSV) infections are rare, and their pathogenesis remains unclear. We studied by immunohistochemistry and in situ hybridization early granulomatous reactions after VZV and HSV infections. In the five cases studied, the VZV glycoproteins gp I and gp II were present in cells abutted to altered vessels, but the corresponding genome sequences were disclosed in similar locations in only one of these cases. In an immunocompromised patient with diffuse HSV eruption, HSV I antigens were present in cells of the reticular dermis, while viral nucleic acids were not evident. Immunophenotyping of the granulomas showed strong Mac 387 and CD68 positive labelings of macrophages/monocytes, without any involvement of Factor XIIIa-positive cells. These findings suggest that the major viral envelope glycoproteins, rather than complete viral particles could trigger granuloma formation following HSV and VZV skin infections.
Disciplines :
Immunology & infectious disease
Dermatology
Author, co-author :
Nikkels, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Debrus, S.
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Sadzot-Delvaux, Catherine ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie et immunologie
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Rentier, Bernard  ;  Université de Liège - ULiège > Département de Microbiologie > Virologie fondamentale et Immunologie
Pierard, Gérald ;  Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie
Language :
English
Title :
Viral glycoproteins in herpesviridae granulomas
Publication date :
December 1994
Journal title :
American Journal of Dermatopathology
ISSN :
0193-1091
eISSN :
1533-0311
Publisher :
Raven Press Publishers
Volume :
16
Issue :
6
Pages :
588-592
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 April 2010

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