Letter to the editor (Scientific journals)
Mapping, fine mapping, and molecular dissection of quantitative trait loci in domestic animals
Georges, Michel
2007In Annual Review of Genomics and Human Genetics, 8, p. 131-162
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Keywords :
positional cloning; genetical genomics; genomic selection
Abstract :
[en] Artificial selection has created myriad breeds of domestic animals, each characterized by unique phenotypes pertaining to behavior, morphology, physiology, and disease. Most domestic animal populations share features with isolated founder populations, making them well suited for positional cloning. Genome sequences are now available for most domestic species, and with them a panoply of tools including high-density single-nucleotide polymorphism panels. As a result, domestic animal populations are becoming invaluable resources for studying the molecular architecture of complex traits and of adaptation. Here we review recent progress and issues in the positional identification of genes underlying complex traits in domestic animals. As many phenotypes studied in animals are quantitative, we focus on mapping, fine mapping, and cloning of quantitative trait loci.
Research center :
Giga-Genetics - ULiège
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Language :
English
Title :
Mapping, fine mapping, and molecular dissection of quantitative trait loci in domestic animals
Publication date :
2007
Journal title :
Annual Review of Genomics and Human Genetics
ISSN :
1527-8204
eISSN :
1545-293X
Publisher :
Annual Reviews, Palo Alto, United States - Florida
Volume :
8
Pages :
131-162
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 December 2009

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