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Analysis of genetic variation in the Belgian Blue Cattle Breed using DNA sequence polymorphism at the growth hormone, low density lipoprotein receptor, -subunit of glycoprotein hormones and thyroglobulin loci
Hilbert, P.; Marcotte, F.; Schwers, A. et al.
1989In Animal Genetics, 20, p. 383-394
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Abstract :
[en] New DNA sequence polymorphisms were identified at four bovine autosomal loci: growth hormone, low density lipoprotein receptor, alpha-subunit of glycoprotein hormones and thyroglobulin. Assuming independent assortment between these polymorphisms, the probabilities to be heterozygous at these four loci are 0.48, 0.36, 0.10 and 0.77 respectively, within the Belgian Blue Cattle breed (BBCB). Nucleotide diversity was estimated, showing that animals from the BBCB are heterozygous for 1/1450 nucleotides, a value significantly lower than the 1/500 value found in man. Moreover, we have estimated that the mutation rate at the cytosines of CG dinucleotides is about 10 times higher than that for other nucleotides.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hilbert, P.
Marcotte, F.
Schwers, A.
Hanset, R.
Vassart, G.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
Analysis of genetic variation in the Belgian Blue Cattle Breed using DNA sequence polymorphism at the growth hormone, low density lipoprotein receptor, -subunit of glycoprotein hormones and thyroglobulin loci
Publication date :
1989
Journal title :
Animal Genetics
ISSN :
0268-9146
eISSN :
1365-2052
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
20
Pages :
383-394
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 December 2009

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