Reference : Earlier onset of delta-retrovirus-induced leukemia after splenectomy.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/32005
Earlier onset of delta-retrovirus-induced leukemia after splenectomy.
English
Florins, ARNAUD-FRANCOIS [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Reichert, Michal [> > > >]
Asquith, Becca [> > > >]
Bouzar, Amel [Université de Liège - ULg > > Gembloux Agro-Bio Tech >]
Jean, Geneviève mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Francois, Carole [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Jasik, Agnieszka [> > > >]
Burny, Arsene [> > > >]
Kettmann, Richard mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Willems, Luc mailto [Université de Liège - ULg > > GIGA-Research - Gembloux Agro-Bio Tech >]
2009
PLoS ONE
Public Library of Science
4
9
e6943
Yes (verified by ORBi)
International
1932-6203
San Franscisco
CA
[en] Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts will develop either lymphoproliferative or neurodegenerative diseases after long latency periods. In fact, the host immune response is believed to tightly control viral replication but this assumption has not been definitely proven in vivo. Here, we provide direct experimental evidence demonstrating that integrity of the spleen is required to control pathogenesis. In the BLV model, we show that asplenia decreases efficiency of the immune response and induces an imbalance in cell dynamics resulting in accelerated onset of leukemia. These observations enlighten a potential threat in splenectomized HTLV-1 carriers and justify a regular preventive evaluation.
http://hdl.handle.net/2268/32005
also: http://hdl.handle.net/2268/18658
10.1371/journal.pone.0006943

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
pone.0006943.pdfPublisher postprint381.17 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.