Article (Scientific journals)
Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads.
Bouzar, Amel; Boxus, Mathieu; Florins, ARNAUD-FRANCOIS et al.
2009In Retrovirology, 6, p. 102
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Abstract :
[en] BACKGROUND: Bovine Leukemia virus (BLV) is a deltaretrovirus that induces lymphoproliferation and leukemia in ruminants. In ex vivo cultures of B lymphocytes isolated from BLV-infected sheep show that spontaneous apoptosis is reduced. Here, we investigated the involvement of reactive oxygen species (ROS) in this process. RESULTS: We demonstrate that (i) the levels of ROS and a major product of oxidative stress (8-OHdG) are reduced, while the thioredoxin antioxidant protein is highly expressed in BLV-infected B lymphocytes, (ii) induction of ROS by valproate (VPA) is pro-apoptotic, (iii) inversely, the scavenging of ROS with N-acetylcysteine inhibits apoptosis, and finally (iv) the levels of ROS inversely correlate with the proviral loads. CONCLUSION: Together, these observations underline the importance of ROS in the mechanisms of inhibition of apoptosis linked to BLV infection.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Bouzar, Amel ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Boxus, Mathieu ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Florins, ARNAUD-FRANCOIS ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Francois, Carole ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Reichert, Michal
Willems, Luc  ;  Université de Liège - ULiège > GIGA-Research - Gembloux Agro-Bio Tech
Language :
English
Title :
Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads.
Publication date :
2009
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
BioMed Central, London, United Kingdom
Volume :
6
Pages :
102
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 December 2009

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