Reference : A sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative p...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/31946
A sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties
English
Masereel, B. [> >]
Schynts, M. [> >]
Krzesinski, Jean-Marie mailto [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >]
Pirotte, Bernard mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Rorive, Georges mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Delarge, J. [> >]
1993
Journal of Pharmacy & Pharmacology
Pharmaceutical Press
45
720-724
Yes (verified by ORBi)
International
0022-3573
London
United Kingdom
[en] diuretic properties ; sulphonylthiourea ; torasemide
[en] A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/31946

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