Reference : Class IIa histone deacetylases: regulating the regulators.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/31916
Class IIa histone deacetylases: regulating the regulators.
English
Martin, Maud mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Kettmann, Richard [Université de Liège > > Gembloux Agro-Bio Tech >]
Dequiedt, Franck mailto [Université de Liège > > Gembloux Agro-Bio Tech et GIGA Research > >]
2007
Oncogene
26
37
Yes (verified by ORBi)
International
0950-9232
[en] HDAC ; Acetylation ; development ; chromatin ; transcription
[en] n the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases (HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional regulators of various developmental and differentiation processes. In the past 5 years, a tremendous effort has been dedicated to characterizing the regulation of these enzymes. In this review, we summarize the latest discoveries in the field and discuss the molecular and structural determinants of class IIa HDACs regulation. Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications.
http://hdl.handle.net/2268/31916
10.1038/sj.onc.1210613

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