Article (Scientific journals)
Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression
Wera, Stefaan; Belayew, Alexandra; Martial, Joseph
1995In FEBS Letters, 358 (2), p. 158-60
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Keywords :
Animals; Cyclic AMP/pharmacology; Cyclosporine/*pharmacology; Gene Expression Regulation/*drug effects; Humans; Polyenes/*pharmacology; Prolactin/*genetics; Promoter Regions, Genetic; Protein Biosynthesis; Rats; Sirolimus; Tacrolimus/*pharmacology; Transcription, Genetic; Tumor Cells, Cultured
Abstract :
[en] In this work we demonstrate that transcription of the human prolactin gene is inhibited by the immunosuppressants FK506 (IC50 = 25 nM), cyclosporin A (IC50 = 190 nM) and rapamycin (IC50 = 25 nM). Whereas the effect of FK506 and cyclosporin A is specific for prolactin gene transcription, rapamycin has a more general effect on transcription and/or translation in pituitary cells. In view of recent work demonstrating the immunoactivating role of prolactin, these results suggest that inhibition of prolactin gene expression in the pituitary may contribute to the mechanism of action of immunosuppressants.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Wera, Stefaan;  Université de Liège - ULiège
Belayew, Alexandra;  Université de Liège - ULiège
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression
Publication date :
1995
Journal title :
FEBS Letters
ISSN :
0014-5793
eISSN :
1873-3468
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
358
Issue :
2
Pages :
158-60
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
www.elsevier.com
Available on ORBi :
since 04 December 2009

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