Reference : A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of me...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/31655
A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm
English
Marine, Jean-Christophe [Université de Liège - ULG > > > >]
Bellefroid, Eric J. [Institut für Biochemie und Molekulare Zellbiologie > > > >]
Pendeville-Samain, Hélène [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Pieler, Tomas [Institut für Biochemie und Molekulare Zellbiologie > > > >]
1997
Mechanisms of Development
Elsevier
63
2
211-25
Yes (verified by ORBi)
0925-4773
1872-6356
Limerick
Ireland
[en] Amino Acid Sequence ; Animals ; *Body Patterning ; Caenorhabditis elegans ; Cloning, Molecular ; *DNA-Binding Proteins ; Drosophila/genetics ; Ectoderm/*physiology ; *Gene Expression Regulation, Developmental ; Humans ; In Situ Hybridization ; Mesoderm/*physiology ; Mice ; Molecular Sequence Data ; Recombinant Fusion Proteins/physiology ; Repressor Proteins/biosynthesis/*genetics ; *Transcription Factors ; Transfection ; Xenopus/*genetics ; *Xenopus Proteins ; Zinc Fingers/genetics/physiology
[en] Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of mesoderm and neural development. Transient transfection assays reveal that XGli-3 and XGli-4 can function as transcription repressors. Counteracting the Gli-protein repressor activity by ectopic expression of a fusion protein that contains the Gli-zinc finger cluster connected to the E1A activator domain in Xenopus embryos results in specific morphological alterations in the developing somites and in the central nervous system. Altered expression characteristics for a broad set of molecular markers highlighting specific aspects of mesodermal and neural differentiation demonstrate an important role for Gli-type zinc finger proteins in the early mesodermal and neural patterning of Xenopus embryos.
http://hdl.handle.net/2268/31655
10.1016/S0925-4773(97)00050-6
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9H-3SRHD25-10&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=292803eb04387ea499db5fdc544fffa4
1997/05/01
www.elsevier.com

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