Article (Scientific journals)
A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm
Marine, Jean-Christophe; Bellefroid, Eric J.; Pendeville-Samain, Hélène et al.
1997In Mechanisms of Development, 63 (2), p. 211-25
Peer Reviewed verified by ORBi
 

Files


Full Text
A role for Xenopus Gli-type.pdf
Publisher postprint (1.21 MB)
Request a copy

1997/05/01


All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Amino Acid Sequence; Animals; *Body Patterning; Caenorhabditis elegans; Cloning, Molecular; *DNA-Binding Proteins; Drosophila/genetics; Ectoderm/*physiology; *Gene Expression Regulation, Developmental; Humans; In Situ Hybridization; Mesoderm/*physiology; Mice; Molecular Sequence Data; Recombinant Fusion Proteins/physiology; Repressor Proteins/biosynthesis/*genetics; *Transcription Factors; Transfection; Xenopus/*genetics; *Xenopus Proteins; Zinc Fingers/genetics/physiology
Abstract :
[en] Gli-type zinc finger proteins play important regulatory roles in vertebrate and invertebrate embryogenesis. In Xenopus, the Gli-type proteins XGli-3 and XGli-4 are first expressed in earliest stages of mesoderm and neural development. Transient transfection assays reveal that XGli-3 and XGli-4 can function as transcription repressors. Counteracting the Gli-protein repressor activity by ectopic expression of a fusion protein that contains the Gli-zinc finger cluster connected to the E1A activator domain in Xenopus embryos results in specific morphological alterations in the developing somites and in the central nervous system. Altered expression characteristics for a broad set of molecular markers highlighting specific aspects of mesodermal and neural differentiation demonstrate an important role for Gli-type zinc finger proteins in the early mesodermal and neural patterning of Xenopus embryos.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Marine, Jean-Christophe;  Université de Liège - ULiège
Bellefroid, Eric J.;  Institut für Biochemie und Molekulare Zellbiologie
Pendeville-Samain, Hélène ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Pieler, Tomas;  Institut für Biochemie und Molekulare Zellbiologie
Language :
English
Title :
A role for Xenopus Gli-type zinc finger proteins in the early embryonic patterning of mesoderm and neuroectoderm
Publication date :
1997
Journal title :
Mechanisms of Development
ISSN :
0925-4773
eISSN :
1872-6356
Publisher :
Elsevier, Limerick, Ireland
Volume :
63
Issue :
2
Pages :
211-25
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
www.elsevier.com
Available on ORBi :
since 04 December 2009

Statistics


Number of views
136 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
41
Scopus citations®
without self-citations
39
OpenCitations
 
45

Bibliography


Similar publications



Contact ORBi