Reference : Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis
Bellefroid, Eric J. [Yale University School of Medicine > > > >]
Sahin, Mustapha [Yale University School of Medicine > > > >]
Poncelet, Dominique A [> >]
Riviere, Michèle [Université Libre de Bruxelles - ULB > > > >]
Bourguignon, Catherine [Yale University School of Medicine > > > >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Morris, Patricia L [The Population Council and The Rockefeller University > > > >]
Pieler, Tomas [Georg-August-Universität Göttingen > > > >]
Szpirer, Claude [Université Libre de Bruxelles > > > >]
Ward, David C [Yale University School of Medicine > > > >]
Biochimica et Biophysica Acta
Yes (verified by ORBi)
[en] Amino Acid Sequence ; Animals ; Base Sequence ; DNA, Complementary ; DNA-Binding Proteins/*genetics/metabolism ; Gene Expression ; Humans ; Male ; Molecular Sequence Data ; Rats ; Spermatogenesis/physiology ; Testis/*metabolism ; *Zinc Fingers
[en] Two novel KRAB (Kruppel associated box) type zinc finger protein encoding cDNAs, named Kzf1 and Kzf2 (Kzf for KRAB zinc finger), were identified by screening of a rat embryonic brain cDNA library with a human ZNF91 KRAB probe. Kzf1 and Kzf2 encode proteins with an amino-terminal KRAB domain and a carboxy-terminal zinc finger cluster containing 9 and 13 zinc finger units, respectively. While Kzf2 appears to be ubiquitously expressed, Kzf1 is preferentially expressed in the testis. Within the testis, Kzf1 mRNA is restricted to germ cells. The Kzf1 protein exhibits DNA binding activity and its KRAB domain can function as a repressor module in transcription. Using somatic cell hybrid analysis, the Kzf1 gene was mapped to chromosome 6.

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