[en] An infectious ætiology for multiple sclerosis (MS) has been postulated but none of the agents putatively
associated with the disease have, as yet, been proven to be causative.1-4 The reported5 isolation of an infectious
agent from bone-marrow aspiration of patients with MS prompted us to attempt recovery of an agent from our
MS patients. We were unable
to isolate an agent from seven MS patients with similar cell lines and procedures. There is no apparent reason for our inability to do so. However, we did find an adventitious agent(s) in two commercial sources of Hela cells.
Although not initially apparent, this agent(s) became active upon incubation with either MS-patient or control
bone-marrow cells and induced large syncytia when passed to other Hela cells.
Disciplines :
Immunology & infectious disease
Author, co-author :
Wallen, William C.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
Sever, John L.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
McFarlin, Dale E.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
McFarland, Henry F.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
Traub, Renée G.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
Rentier, Bernard ; Université de Liège - ULiège > National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
Greenstein, Jeffrey L.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
Moore, Patricia M.; National Institutes of Health, National Institute of Neurological and Communicative Disorders and Stroke,
Language :
English
Title :
Attempt to isolate infectious agent from bone-marrow of patients with multiple sclerosis
Hall, Dederick, Nevinney Cancer Chemother Rep 1963, 30:21.
Teatle, Mendelssohn, Green (1978) Hypercalcemia and Tamoxifen Readministered. Annals of Internal Medicine 88:287.
Brody, Sever, Edgar, McNew (1972) Measles antibody titers of multiple sclerosis patients and their siblings. Neurology 22.
Koldovsky, Koldovsky, Henle (1975) Multiple sclerosis associated agent: transmission to animals and some properties of the agent. Infect Immun 12:1355-1366.
Carp, Licursi, Merz, Merz (1972) Decreased percentage of polymorphonuclear neutrophils in mouse peripheral blood after inoculation with material from multiple sclerosis patients. J Exp Med 136:618-629.
Pertschuck, Cook, Gupta (1976) Measles antigen in multiple sclerosis identification in the jejunum by immunofluorescence. Life Sciences 19:1603-1608.
Mitchell, Porterfield, Micheletti (1978) Isolation of an infectious agent from bone-marrows of patients with multiple sclerosis. Lancet 2:387-390.
Report and Recommendations: National Advisory Commission on Multiple Sclerosis, U.S. Government Printing Office, Washington, D.C, DHEW Pub. No 74-534; 1974.
