Article (Scientific journals)
Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.
Scuvée-Moreau, Jacqueline; Seutin, Vincent; Vrijens, Bernard et al.
1997In Archives of Physiology and Biochemistry, 105 (5), p. 421-8
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Keywords :
Action Potentials/drug effects; Animals; Cromakalim/pharmacology; Diazoxide/pharmacology; Dopamine/metabolism; Guanidines/pharmacology; Hippocampus/cytology/drug effects/physiology; Male; Neurons/drug effects/physiology; Pinacidil; Potassium Channels/drug effects; Pyramidal Cells/drug effects/physiology; Pyridines/pharmacology; Rats; Rats, Wistar; Thiadiazines/pharmacology; Ventral Tegmental Area/cytology/drug effects/physiology
Abstract :
[en] The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices. Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells. They all had a similar potency. Only BPDZ44 and diazoxide inhibited the firing rate of A10 dopamine neurons. The sulfonylurea glipizide (1 microM) antagonized the effect of BPDZ44 and diazoxide on A10 neurons but failed to antagonize the effect of KCOs on CA1 pyramidal cells. These results show that differences exist among KCOs in their ability to decrease the electrical activity of various populations of central neurons.
Disciplines :
General & internal medicine
Pharmacy, pharmacology & toxicology
Author, co-author :
Scuvée-Moreau, Jacqueline ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie - Département des sciences biomédicales et précliniques
Seutin, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie
Vrijens, Bernard  ;  Université de Liège - ULiège > Département de mathématique > Département de mathématique
Pirotte, Bernard ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
De Tullio, Pascal ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Massotte, Laurent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Delarge, J
Dresse, Albert ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.
Publication date :
1997
Journal title :
Archives of Physiology and Biochemistry
ISSN :
1381-3455
eISSN :
1744-4160
Publisher :
Taylor & Francis, Abingdon, United Kingdom
Volume :
105
Issue :
5
Pages :
421-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 December 2009

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