Reference : Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells an...
Scientific journals : Article
Human health sciences : General & internal medicine
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/31187
Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.
English
Scuvée-Moreau, Jacqueline mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie - Département des sciences biomédicales et précliniques >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie]
Vrijens, Bernard [Université de Liège - ULg > Département de mathématique > Département de mathématique]
Pirotte, Bernard mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique]
De Tullio, Pascal mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique]
Massotte, Laurent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques]
Albert, Adelin mailto [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique]
Delarge, J [> > > >]
Dresse, Albert mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)]
1997
Archives of Physiology & Biochemistry
Taylor & Francis
105
5
421-8
Yes (verified by ORBi)
International
1381-3455
Abingdon
United Kingdom
[en] Action Potentials/drug effects ; Animals ; Cromakalim/pharmacology ; Diazoxide/pharmacology ; Dopamine/metabolism ; Guanidines/pharmacology ; Hippocampus/cytology/drug effects/physiology ; Male ; Neurons/drug effects/physiology ; Pinacidil ; Potassium Channels/drug effects ; Pyramidal Cells/drug effects/physiology ; Pyridines/pharmacology ; Rats ; Rats, Wistar ; Thiadiazines/pharmacology ; Ventral Tegmental Area/cytology/drug effects/physiology
[en] The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices. Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells. They all had a similar potency. Only BPDZ44 and diazoxide inhibited the firing rate of A10 dopamine neurons. The sulfonylurea glipizide (1 microM) antagonized the effect of BPDZ44 and diazoxide on A10 neurons but failed to antagonize the effect of KCOs on CA1 pyramidal cells. These results show that differences exist among KCOs in their ability to decrease the electrical activity of various populations of central neurons.
http://hdl.handle.net/2268/31187
also: http://hdl.handle.net/2268/139825
10.1076/apab.105.5.421.3285

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