Article (Scientific journals)
Seminoma arising in corrected and uncorrected inguinal cryptorchidism: Treatment and prognosis in 66 patients
Li; COUCKE, Philippe; Tu-Nan, Qian et al.
1997In International Journal of Radiation, Oncology, Biology, Physics, 38 (2), p. 343-350
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Keywords :
Seminoma; Cryptorchidism; Radiotherapy
Abstract :
[en] The purpose of this study was to analyze prognosis and treatment results for seminoma arising in corrected and uncorrected inguinal cryptorchidism (SCIC and SUIC). Image : We reviewed 66 patients with inguinal seminomas between June 1958 and December 1991 at the Cancer Hospital and Institute of Chinese Academy of Medical Sciences. Of these patients, 23 had prior orchiopexy and 43 presented with an inguinal form of cryptorchidism. At presentation, 17 of 66 (26%) patients had nodal metastases. This nodal involvement was 30% (7 of 23) for SCIC and 23% (10 of 43) for SUIC, respectively. These numbers are comparable with those in a series of patients treated for scrotal seminoma at our institution (26% vs. 20%). However, 3 of 23 (13%) patients who had prior orchiopexy presented with inguinal nodal metastasis as compared with 0 of 43 patients with SUIC or 4 of 237 patients with scrotal seminoma (p < 0.5). There were 49 stage I, 5 stage IIA, 8 stage IIB, 3 stage III, and 1 stage IV patients. All patients underwent radical orchiectomy and received further radiotherapy, chemotherapy, or both. Patients with stage I and stage II disease were treated primarily with radiotherapy, whereas patients with stage III and IV disease were treated with chemotherapy. Image : The overall and disease-free survival at 5 and 10 years was 94% and 92%, 89% and 87%, respectively. The overall 5- and 10-year survival by stage was 100% and 100% for stage I, and 77% and 68% for stage II, respectively (p < .05). There was no significant difference in survival between SUIC and SCIC (93% vs. 96% at 5 years). Four patients developed relapse. Two of these four patients experienced relapse at the inguinal area, due to a marginal miss. Three of four patients with relapse were successfully salvaged, and one died of disease. Image : Our results indicate that prognosis for inguinal seminoma is excellent and similar to that of scrotal seminoma. Postorchiectomy radiotherapy can be considered as the standard treatment for stage I and IIA inguinal seminoma. We recommend routinely including the para-aortic and ipsilateral pelvic nodes.
Disciplines :
Hematology
Oncology
Author, co-author :
Li;  Cancer Hospital and Institute, Chinese Academy of Medical Sciences
COUCKE, Philippe  ;  Centre Hospitalier Universitaire Vaudois > Radiothérapie
Tu-Nan, Qian;  Cancer Hospital and Institute, Chinese Academy of Medical Sciences > Radiation Oncology
Huang, Yi-Rong;  Cancer Hospital and Institute, Chinese Academy of Medical Sciences > Radiation Oncology
Gu, Da-Zhong;  Cancer Hospital and Institute, Chinese Academy of Medical Sciences > Radiation Oncology
Mirimanoff, René-Olivier;  Centre Hospitalier Universitaire Vaudois > Radiation Oncology
Yu, Zi-Hao;  Cancer Hospital and Institute, Chinese Academy of Medical Sciences > Radiation Oncology
Language :
English
Title :
Seminoma arising in corrected and uncorrected inguinal cryptorchidism: Treatment and prognosis in 66 patients
Publication date :
1997
Journal title :
International Journal of Radiation, Oncology, Biology, Physics
ISSN :
0360-3016
eISSN :
1879-355X
Publisher :
Elsevier Science, Tarrytown, United States - New York
Volume :
38
Issue :
2
Pages :
343-350
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 February 2010

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