Reference : Focalized external radiotherapy for resected solitary brain metastasis: does the dogma s...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/31016
Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand?
English
Coucke, Philippe mailto [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >]
Zouhair, Abderrahim [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >]
Ozsahin, Mahmut [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >]
De Tribolet, Nicoles [Centre Hospitalier Universitaire Vaudois > Neurosurgery > > >]
Mirimanoff, René [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >]
Apr-1998
Radiotherapy & Oncology
Elsevier Scientific
47
1
99-101
Yes (verified by ORBi)
International
0167-8140
Limerick
Ireland
[en] Focalized external irradiation ; Resected solitary brain metastasis ; Dogma
[en] To investigate whether whole brain irradiation might be replaced by focalized irradiation after resection of a single brain metastasis in patients where extracranial tumor control is deemed to be obtained.

Patients and methods: Twelve patients were introduced in a phase I/II prospective study of conformal postoperative external irradiation after resection of a solitary brain metastasis. The radiation treatment consisted of 50.4 Gy (1.8 Gy per fraction, five fractions per week). The planning target volume consisted of the tumor bed and a 2 cm safety margin. All treatments were optimized with head immobilization, dedicated tomodensitometry and computer assisted three-dimensional treatment planning.

Results: The median survival was 7.2 months (range 2.4–50.4 months). Eleven of the 12 patients died. Eight of the 12 patients presented intracranial recurrence and seven died as a consequence of intracranial tumor progression.

Conclusions: Focalized external irradiation cannot serve as a reasonable alternative to whole brain radiotherapy (WBRT) even for patients with apparently one single resected brain metastasis. The dogma of ‘one metastasis=multiple metastases' seems to be confirmed.
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/2268/31016

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