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| Reference : Focalized external radiotherapy for resected solitary brain metastasis: does the dogma s... |
| Scientific journals : Article | |||
| Human health sciences : Oncology | |||
| http://hdl.handle.net/2268/31016 | |||
| Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand? | |
| English | |
Coucke, Philippe  [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >] | |
| Zouhair, Abderrahim [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >] | |
| Ozsahin, Mahmut [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >] | |
| De Tribolet, Nicoles [Centre Hospitalier Universitaire Vaudois > Neurosurgery > > >] | |
| Mirimanoff, René [Centre Hospitalier Universitaire Vaudois > Radiation Oncology > > >] | |
| Apr-1998 | |
| Radiotherapy & Oncology | |
| Elsevier Scientific | |
| 47 | |
| 1 | |
| 99-101 | |
| International | |
| 0167-8140 | |
| Limerick | |
| Ireland | |
| [en] Focalized external irradiation ; Resected solitary brain metastasis ; Dogma | |
| [en] To investigate whether whole brain irradiation might be replaced by focalized irradiation after resection of a single brain metastasis in patients where extracranial tumor control is deemed to be obtained.
Patients and methods: Twelve patients were introduced in a phase I/II prospective study of conformal postoperative external irradiation after resection of a solitary brain metastasis. The radiation treatment consisted of 50.4 Gy (1.8 Gy per fraction, five fractions per week). The planning target volume consisted of the tumor bed and a 2 cm safety margin. All treatments were optimized with head immobilization, dedicated tomodensitometry and computer assisted three-dimensional treatment planning. Results: The median survival was 7.2 months (range 2.4–50.4 months). Eleven of the 12 patients died. Eight of the 12 patients presented intracranial recurrence and seven died as a consequence of intracranial tumor progression. Conclusions: Focalized external irradiation cannot serve as a reasonable alternative to whole brain radiotherapy (WBRT) even for patients with apparently one single resected brain metastasis. The dogma of ‘one metastasis=multiple metastases' seems to be confirmed. | |
| Researchers ; Professionals ; Students ; General public ; Others | |
| http://hdl.handle.net/2268/31016 |
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