ORBi: Munaut Carine - Presence of Oestrogen Receptor Type Beta in Human Retina

Reference : Presence of Oestrogen Receptor Type Beta in Human Retina


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology Human health sciences : Ophthalmology
	To cite this reference:	http://hdl.handle.net/2268/30933

Title :	Presence of Oestrogen Receptor Type Beta in Human Retina
Language :	English
Author, co-author :	Munaut, Carine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Lambert, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Frankenne, Francis [> > > >]
	Deprez, Manuel [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
	Rakic, Jean-Marie [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Publication date :	2001
Journal title :	British Journal of Ophthalmology
Publisher :	British Medical Association
Volume :	85
Issue/season :	7
Pages :	877-82
Audience :	International
ISSN :	0007-1161
e-ISSN :	1468-2079
City :	London
Country :	United Kingdom
Keywords :	[en] Aged ; Blotting, Western/methods ; Immunohistochemistry/methods ; Male ; Middle Aged ; oestrogen receptor ; ocular ; RNA, Messenger/analysis ; Receptors, Estrogen/analysis/genetics ; Retina/chemistry ; Retinal Ganglion Cells/chemistry ; Reverse Transcriptase Polymerase Chain Reaction
Abstract :	[en] BACKGROUND/AIMS: Recent studies have demonstrated the existence of two oestrogen receptor subtypes alpha (ORalpha) and beta (ORbeta) with significant differences of expression among organs. Since important pathologies of human eye could be linked to hormonal status, the expression of ORbeta in ocular posterior segment was sought. METHODS: Immunohistochemical localisation of ORbeta and ORalpha protein and detection of OR mRNAs by reverse transcription-polymerase chain reaction (RT-PCR) were performed in macular and extramacular regions of the retina and in the choroid on male and female donors eyes. RESULTS: ORbeta protein was localised in the ganglion cell layer and in the choroid. At the transcriptional level, mRNA for ORbeta and for ORalpha were both present. Local differences in the expression level were observed, however, suggesting the possibility of variation in the ratio of ORalpha v ORbeta. CONCLUSIONS: The coexistence of two oestrogen receptor subtypes in the human ocular posterior segment raises acute questions about their potential physiological role, but offers a perspective for preferential targeting of a specific receptor subtype.
Permalink :	http://hdl.handle.net/2268/30933
	also: http://hdl.handle.net/2268/5180
Other URL :	http://bjo.bmj.com/cgi/content/full/85/7/877

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Open access	Munaut C BrJO 2001.pdf		Publisher postprint	338 kB	View/Open

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