Article (Scientific journals)
Extending the nuclear roles of I kappa B kinase subunits
Gloire, Geoffrey; Dejardin, Emmanuel; Piette, Jacques
2006In Biochemical Pharmacology, 72 (9), p. 1081-1089
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Keywords :
NF-kappa B; IKK; inflammation; cytokines; nucleus; DNA damage
Abstract :
[en] The transcription factor NF-kappa B plays a key role in a wide variety of cellular processes such as innate and adaptive immunity, cellular proliferation, apoptosis and development. In unstimulated cells, NF-kappa B is sequestered in the cytoplasm through its tight association with inhibitory proteins called I kappa BS, comprising notably I kappa B alpha. A key step in NF-kappa B activation is the phosphorylation Of I kappa B alpha by the so-called I kappa B kinase (IKK) complex, which targets the inhibitory protein for proteasomal degradation and allows the freed NF-kappa B to enter the nucleus where it can transactivate its target genes. The IKK complex is composed of two catalytic subunits called IKK alpha and IKK beta, and a regulatory subunit called NEMO/IKK gamma. Despite their key role in mediating I kappa B alpha phosphorylation in the cytoplasm, recent works have provided evidence that IKK subunits also translocate into the nucleus to regulate NF-kappa B-dependent and -independent gene expression, paving the way of a novel and exciting field of research. In this review, we will describe the current knowledge in that research area. (c) 2006 Elsevier Inc. All rights reserved.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gloire, Geoffrey ;  Université de Liège - ULiège > Virologie - Immunologie
Dejardin, Emmanuel ;  Université de Liège - ULiège > Virologie - Immunologie
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > Virologie - Immunologie
Language :
English
Title :
Extending the nuclear roles of I kappa B kinase subunits
Publication date :
30 October 2006
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
Volume :
72
Issue :
9
Pages :
1081-1089
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 February 2010

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