Radiologic features poorly predict clinical outcomes in knee osteoarthritis.

Aged; Arthrography/methods; Disability Evaluation; Disease Progression; Double-Blind Method; Glucosamine/therapeutic use; Humans; Knee Joint/physiopathology/radiography; Osteoarthritis, Knee/drug therapy/physiopathology/radiography; Pain Measurement; Questionnaires; Reproducibility of Results; Severity of Illness Index; Treatment Outcome

Abstract :

[en] OBJECTIVES: To assess the impact of radiographic severity and progression on pain and disability. METHODS: Measurements of mean joint space width (JSW), narrowest join space (NJS) point and assessment of symptoms by the WOMAC questionnaire were performed at baseline and after three years in 212 subjects over 50 years with primary knee OA. RESULTS: At baseline, JSW and NJS were not significantly correlated with the scores recorded for the WOMAC global index or its pain, stiffness or function subscales. A statistically significant correlation was observed between the joint space narrowing over three years and the changes observed in the pain subscale of the WOMAC during the same period. The three-year changes in the global WOMAC index in patients within the lowest and the highest quartiles of mean joint space width at baseline showed, in both cases, a statistically (p<0.05) significant favorable difference between patients treated with glucosamine sulphate and those having received placebo. CONCLUSION: Radiographic and clinical progressions of the disease are significantly associated but the clinical relevance of the association is questionable.

Disciplines :

Public health, health care sciences & services
General & internal medicine

Author, co-author :

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique

Honore, Aline

Rovati, Lucio C

Giacovelli, Giampaolo

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie

Seidel, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Non budgétaires

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique

Language :

English

Title :

Radiologic features poorly predict clinical outcomes in knee osteoarthritis.

Publication date :

2002

Journal title :

Scandinavian Journal of Rheumatology

ISSN :

0300-9742

eISSN :

1502-7732

Publisher :

Taylor & Francis, Oslo, Norway

Volume :

Issue :

Pages :

13-6

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 01 December 2009

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