ORBi: Bruyère Olivier - Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.

Reference : Correlation between radiographic severity of knee osteoarthritis and future disease prog...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Public health, health care sciences & services Human health sciences : General & internal medicine
	To cite this reference:	http://hdl.handle.net/2268/30647

Title :	Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate.
Language :	English
Author, co-author :	Bruyère, Olivier [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
	Honore, Aline [> > > >]
	Ethgen, Olivier [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique : aspects spécifiques >]
	Rovati, Lucio C [> > > >]
	Giacovelli, Giampaolo [> > > >]
	Henrotin, Yves [Université de Liège - ULg > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie >]
	Seidel, Laurence [Centre Hospitalier Universitaire de Liège - CHU > > Non budgétaires >]
	Reginster, Jean-Yves [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
Publication date :	Jan-2003
Journal title :	Osteoarthritis and Cartilage
Publisher :	W.B. Saunders
Volume :	11
Issue/season :	1
Pages :	1-5
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1063-4584
City :	London
Country :	United Kingdom
Keywords :	[en] Aged ; Disease Progression ; Double-Blind Method ; Female ; Glucosamine/therapeutic use ; Humans ; Male ; Osteoarthritis, Knee/drug therapy/radiography ; Prognosis ; Prospective Studies
Abstract :	[en] OBJECTIVE: To investigate the relationship between baseline radiographic severity of knee osteoarthritis (OA) and the importance of long-term joint space narrowing. DESIGN: Sub-analysis from a three-year randomized, placebo-controlled, prospective study, of 212 patients with knee OA, recruited in an osteoarthritic outpatient clinic and having been part of a study evaluating the effect of glucosamine sulfate on symptom and structure modification in knee OA. MATERIAL AND METHODS: Measurements of mean joint space width (JSW), assessed by a computer-assisted method, were performed at baseline and after 3 years, on weightbearing anteroposterior knee radiographs. RESULTS: In the placebo group, baseline JSW was significantly and negatively correlated with the joint space narrowing observed after 3 years (r=-0.34, P=0.003). In the lowest quartile of baseline mean JSW (<4.5mm), the JSW increased after 3 years by (mean (S.D.)) 3.8% (23.8) in the placebo group and 6.2% (17.5) in the glucosamine sulfate group. The difference between the two groups in these patients with the most severe OA at baseline was not statistically significant (P=0.70). In the highest quartile of baseline mean JSW (>6.2mm), a joint space narrowing of 14.9% (17.9) occurred in the placebo group after 3 years while patients from the glucosamine sulfate group only experienced a narrowing of 6.0% (15.1). Patients with the most severe OA at baseline had a RR of 0.42 (0.17-1.01) to experience a 0.5mm joint space narrowing over 3 years, compared to those with the less affected joint. In patients with mild OA, i.e. in the highest quartile of baseline mean JSW, glucosamine sulfate use was associated with a trend (P=0.10) towards a significant reduction in joint space narrowing. CONCLUSION: These results suggest that patients with the less severe radiographic knee OA will experience, over 3 years, the most dramatic disease progression in terms of joint space narrowing. Such patients may be particularly responsive to structure-modifying drugs.
Permalink :	http://hdl.handle.net/2268/30647
DOI :	10.1053/joca.2002.0848
Commentary :	Copyright 2003 OsteoArthritis Research Society International. Published by Elsevier Science Ltd.

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