Reference : Clinical applications of pinhole single photon emission tomography
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Clinical applications of pinhole single photon emission tomography
Seret, Alain mailto [Université de Liège - ULg > Département de physique > Imagerie médicale expérimentale >]
Hustinx, Roland mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine nucléaire]
Current Medical Imaging Reviews
Bentham Science Publ Ltd
Yes (verified by ORBi)
[en] Pinhole ; Single photon emission tomography ; SPECT ; Pinhole-SPECT ; Axillary lymph node scintigraphy ; Bone scintigraphy ; Parathyroid scintigraphy ; Thyroid scintigraphy
[en] For some planar scintigraphic explorations, like thyroid or hip, the pinhole collimator is usually preferred to the usual parallel hole collimators because it allows a superior resolution. Progress in 3D tomography reconstruction methods allows single photon emission tomography (SPET) to be today performed using the-pinhole collimator with again the advantage of a higher resolution. Pinhole collimator imposes a short distance (a few centimetres) to the target area and a restricted field of view. Over the last ten years, the potential of pinhole SPET has been essentially investigated for the ankle and the hind foot, the detection of thyroid nodules or abnormal parathyroid glands, the exploration of axillary lymph nodes. The technique was usually compared to planar scintigraphy performed with parallel hole or pinhole collimator. Sometimes a comparison to standard (with parallel hole collimator) SPET or to a morphologic imaging technique was also available. All studies highlight the improvement in resolution afforded by the use of the pinhole collimator. In bone scintigraphy, the delineation of the structures was largely superior allowing the visualisation of significant details usually never seen on scintigraphic images. In thyroid scintigraphy, the better resolution allowed to detect more nodules (essentially infra-centimetre nodules), and to reduce the number of equivocal cases. For abnormal parathyroid gland detection, the number of false negative cases decreased, with a concomitant increase of true positive cases; the glands were more sharply delineated on the images. Pinhole SPET with Tc-99m-tetrofosmin was the only scintigraphic method able to successfully reveal the number of involved lymph nodes in patients with breast cancer. In conclusion pinhole single photon appears as a promising new scintigraphic method allowing to explore small areas with a high resolution.
Researchers ; Professionals ; Students ; General public
Review article. The original publication is available at
The authors thank Bentham Science Publishers for allowing deposit of their final version on the institutional repository.

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