hemodynamics; ventricular function; blood flow; blood pressure; contractile function
Abstract :
[en] Maximal left ventricular (LV) hydraulic power output (PWRmax), corrected for preload as PWRmax/(V-ed)(beta) (where V-ed is the end-diastolic volume and beta is a constant coefficient), is an index of LV contractility. Whereas preload-adjusted maximal power (PAMP) is usually calculated with beta = 2, there is uncertainty about the optimal value of beta (beta = 1 for the normal LV and 2 for the dilated LV). The aim of this work is to study the determining factors of beta. The data set consisted of 245 recordings (steady state and vena cava occlusion) in 10 animals in an ischemic heart pig model. The occlusion data yielded the slope (E-es; 2.01 +/- 0.77 mmHg/ml, range 0.71-4.16 mmHg/ml) and intercept (V-0; -11.9 +/- 22.6 ml; range -76 to 39 ml) of the end-systolic pressure-volume relation, and the optimal beta-factor (assessed by fitting an exponential curve through the V-ed-PWRmax relation) was 1.94 +/- 0.88 (range 0.29-4.73). The relation of beta with V-ed was weak [beta = 0.60 + 0.02(V-ed); r(2) = 0.20]. In contrast, we found an excellent exponential relation between V-0 and beta [beta = 2.16e(0.0189(V0)), r(2) = 0.70]. PAMP, calculated from the steady-state data, was 0.64 +/- 0.40 mW/ml(2) (range 0.14-2.83 mW/ml(2)) with a poor correlation with E-es (r = 0.30, P < 0.001). An alternative formulation of PAMP as PWRmax/(V-ed - V-0)(2), incorporating V-0, yielded 0.47 +/- 0.26 mW/ml(2) (range 0.09-1.42 mW/ml(2)) and was highly correlated with E-es (r = 0.89, P < 0.001). In conclusion, correct preload adjustment of maximal LV power requires incorporation of V-0 and thus of data measured under altered loading conditions.
Disciplines :
Cardiovascular & respiratory systems Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Segers, Patrick; Ghent University > Institute Biomedical Technology > Hydraulics Laboratory
Leather, H. Alex; Katholieke Universiteit Leuven - KUL > Centre for Experimental Surgery and Anaesthesiology
Lambermont, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Ghuysen, Alexandre ; Université de Liège - ULiège > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière
Dogné, Jean-Michel ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Benoit, Patricia
Morimont, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Wouters, Patrick F.; Katholieke Universiteit Leuven - KUL > Centre for Experimental Surgery and Anaesthesiology
Verdonck, Pascal
Kolh, Philippe ; Université de Liège - ULiège > Département des Sciences biomédicales et précliniques > Service de Biochimie et de Physiologie humaines, normale et pathologique
Language :
English
Title :
Determinants of left ventricular preload-adjusted maximal power
Publication date :
June 2003
Journal title :
American Journal of Physiology - Heart and Circulatory Physiology
ISSN :
0363-6135
eISSN :
1522-1539
Publisher :
Amer Physiological Soc, Bethesda, United States - Maryland
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