Reference : Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/30008
Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity
English
Serradji, Nawal [> > > >]
Bensaid, Okkacha [> > > >]
Martin, Marc [ > > ]
Sallem, Wafa [ > > ]
Dereuddre-Bosquet, Nathalie [ > > ]
Benmehdi, Houcine [ > > ]
Redeuilh, Catherine [ > > ]
Lamouri, Aazdine [ > > ]
Dive, Georges mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Clayette, Pascal [ > > ]
Heymans, Françoise [ > > ]
1-Dec-2006
Bioorganic & Medicinal Chemistry
Pergamon-Elsevier Science Ltd
14
23
8109-8125
Yes (verified by ORBi)
International
0968-0896
Oxford
[en] anti-HIV-1 ; anti-PAF ; brain ; AIDS dementia complex
[en] HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series. (c) 2006 Elsevier Ltd. All rights reserved.
IAP
Researchers ; Professionals
http://hdl.handle.net/2268/30008

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