ORBi: Serradji Nawal - Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity

Reference : Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PA...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/30008

Title :	Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity
Language :	English
Author, co-author :	Serradji, Nawal [> > > >]
	Bensaid, Okkacha [> > > >]
	Martin, Marc [ > > ]
	Sallem, Wafa [ > > ]
	Dereuddre-Bosquet, Nathalie [ > > ]
	Benmehdi, Houcine [ > > ]
	Redeuilh, Catherine [ > > ]
	Lamouri, Aazdine [ > > ]
	Dive, Georges [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
	Clayette, Pascal [ > > ]
	Heymans, Françoise [ > > ]
Publication date :	1-Dec-2006
Journal title :	Bioorganic & Medicinal Chemistry
Publisher :	Pergamon-Elsevier Science Ltd
Volume :	14
Issue/season :	23
Pages :	8109-8125
Audience :	International
ISSN :	0968-0896
City :	Oxford
Keywords :	[en] anti-HIV-1 ; anti-PAF ; brain ; AIDS dementia complex
Abstract :	[en] HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series. (c) 2006 Elsevier Ltd. All rights reserved.
Funders :	IAP
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/30008

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	bioorg_med_chem_2006_14_8109.pdf		Publisher postprint	723.87 kB	View/Open

All documents in ORBi are protected by a user license.