Reference : Structure-activity relationships in platelet-activating factor. Part 14: Synthesis an...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Biochemistry, biophysics & molecular biology
Structure-activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity
Sallem, Wafa [> > > >]
Serradji, Nawal [> > > >]
Dereuddre-Bosquet, Nathalie [> > > >]
Dive, Georges [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Clayette, Pascal [> > > >]
Heymans, Françoise [> > > >]
Bioorganic & Medicinal Chemistry
Pergamon-Elsevier Science Ltd
Yes (verified by ORBi)
[en] piperazine ; anti-PAF ; anti-HIV-1 ; AIDS dementia complex
[en] As HIV-associated dementia prevalence has risen with the lifespan of HIV-infected individuals, there is an important need for antiretroviral and anti-inflammatory drugs targeting the central nervous system. Platelet-activating factor, a mediator of inflammation, is an HIV-induced neurotoxin secreted in the infected brain. In this work, we developed piperazine derivatives bearing a heterocyclic moiety as PAF-antagonists and HIV-1 replication inhibitors with micromolar potency. (c) 2006 Elsevier Ltd. All rights reserved.
Researchers ; Professionals

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