ORBi: Sallem Wafa - Structure-activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity

Reference : Structure-activity relationships in platelet-activating factor. Part 14: Synthesis and b...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/29961

Title :	Structure-activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity
Language :	English
Author, co-author :	Sallem, Wafa [> > > >]
	Serradji, Nawal [> > > >]
	Dereuddre-Bosquet, Nathalie [> > > >]
	Dive, Georges [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
	Clayette, Pascal [> > > >]
	Heymans, Françoise [> > > >]
Publication date :	1-Dec-2006
Journal title :	Bioorganic & Medicinal Chemistry
Publisher :	Pergamon-Elsevier Science Ltd
Volume :	14
Issue/season :	23
Pages :	7999-8013
Audience :	International
ISSN :	0968-0896
City :	Oxford
Keywords :	[en] piperazine ; anti-PAF ; anti-HIV-1 ; AIDS dementia complex
Abstract :	[en] As HIV-associated dementia prevalence has risen with the lifespan of HIV-infected individuals, there is an important need for antiretroviral and anti-inflammatory drugs targeting the central nervous system. Platelet-activating factor, a mediator of inflammation, is an HIV-induced neurotoxin secreted in the infected brain. In this work, we developed piperazine derivatives bearing a heterocyclic moiety as PAF-antagonists and HIV-1 replication inhibitors with micromolar potency. (c) 2006 Elsevier Ltd. All rights reserved.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/29961

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