Reference : Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive defic...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/29852
Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function.
English
Adamantidis, Antoine [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Thomas, Elizabeth [> > > >]
Foidart, Agnès mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >]
Tyhon, Amélie mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Coumans, Bernard mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Minet, Arlette [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Seutin, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Grisar, Thierry mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Lakaye, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
2005
European Journal of Neuroscience
Blackwell Science
21
10
2837-44
Yes (verified by ORBi)
International
0953-816X
1460-9568
Paris
France
[en] Animals ; Anxiety ; Avoidance Learning/physiology ; Electroshock ; Exploratory Behavior ; Gene Deletion ; Habituation, Psychophysiologic ; Hippocampus/drug effects/physiology ; In Situ Hybridization ; Mice ; Mice, Knockout ; N-Methylaspartate/pharmacology ; Pyramidal Cells/drug effects/physiology ; Receptors, Somatostatin/deficiency/genetics ; Tetrodotoxin/pharmacology
[en] In order to investigate the physiological properties of the melanin-concentrating hormone (MCH) we have generated and used mice from which the MCH receptor 1 gene was deleted (MCHR1(Neo/Neo) mice). Complementary experimental approaches were used to investigate alterations in the learning and memory processes of our transgenic model. The ability of the knockout strain to carry out the inhibitory passive avoidance test was found to be considerably impaired although no significant differences were observed in anxiety levels. This impaired cognitive property prompted us to explore modifications in N-methyl D-aspartate (NMDA) responses in the hippocampus. Intracellular recordings of CA1 pyramidal neurons in hippocampal slices from the MCHR1(Neo/Neo) mice revealed significantly decreased NMDA responses. Finally, using in situ hybridization we found a 15% reduction in NMDAR1 subunit in the CA1 region. These results show for the first time a possible role for MCH in the control of the function of the NMDA receptor.
http://hdl.handle.net/2268/29852
also: http://hdl.handle.net/2268/37798 ; http://hdl.handle.net/2268/5144
10.1111/j.1460-9568.2005.04100.x

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