Reference : Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer ce...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/2985
Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection.
English
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Bartlett, Nathan W [> > > >]
Clark, Richard H [> > > >]
Smith, Geoffrey L mailto [Imperial College London > > > > > >]
2008
Journal of General Virology (The)
Society for General Microbiology
89
Pt 11
2877-81
Yes (verified by ORBi)
International
0022-1317
1465-2099
London
United Kingdom
[en] Vaccinia virus ; Natural killer ; poxvirus
[fr] CD69
[en] The vaccinia virus (VACV) N1 protein is an intracellular virulence factor that has a Bcl-2-like structure and inhibits both apoptosis and signalling from the interleukin 1 receptor, leading to nuclear factor kappa B activation. Here, we investigated the immune response to intranasal infection with a virus lacking the N1L gene (vDeltaN1L) compared with control viruses expressing N1L. Data presented show that deletion of N1L did not affect the proportion of CD4+ and CD8+ T cells infiltrating the lungs or the cytotoxic T-cell activity of these cells. However, vDeltaN1L induced an increased local natural killer cell activity between days 4 and 6 post-infection. In addition, in the absence of N1 the host inflammatory infiltrate was characterized by a reduced proportion of lymphocytes bearing the early activation marker CD69. Notably, there was a good correlation between the level of CD69 expression and weight loss. The implications of these findings are discussed.
Wellcome trust
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/2985
10.1099/vir.0.2008/004119-0

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