Adult neurogenesis and the diseased brain.

[en] For a long time it was believed that the adult mammalian brain was completely unable to regenerate after insults. However, recent advances in the field of stem cell biology, including the identification of adult neural stem cells (NSCs) and evidence regarding a continuous production of neurons throughout life in the dentate gyrus (DG) and the subventricular zone of the lateral ventricles (SVZ), have provided new hopes for the development of novel therapeutic strategies to induce regeneration in the damaged brain. Moreover, proofs have accumulated this last decade that endogenous stem/progenitor cells of the adult brain have an intrinsic capacity to respond to brain disorders. Here, we first briefly summarize our current knowledge related to adult neurogenesis before focusing on the behaviour of adult neural stem/progenitors cells following stroke and seizure, and describe some of the molecular cues involved in the response of these cells to injury. In the second part, we outline the consequences of three main neurodegenerative disorders on adult neurogenesis and we discuss the potential therapeutic implication of adult neural stem/progenitors cells during the course of these diseases.

Research center :

Giga-Neurosciences - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology
Neurology

Author, co-author :

Vandenbosch, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Borgs, Laurence ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Beukelaers, Pierre ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Belachew, Shibeshih ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Moonen, Gustave ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Nguyen, Laurent ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Malgrange, Brigitte ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie

Language :

English

Title :

Adult neurogenesis and the diseased brain.

Publication date :

2009

Journal title :

Current Medicinal Chemistry

ISSN :

0929-8673

eISSN :

1875-533X

Publisher :

Bentham Science Publishers Ltd., Schiphol, Netherlands

Volume :

Issue :

Pages :

652-66

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]
Fonds Léon Fredericq [BE]

Available on ORBi :

since 27 November 2009

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