Reference : Cell "circadian" cycle: new role for mammalian core clock genes.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Neurology
http://hdl.handle.net/2268/29790
Cell "circadian" cycle: new role for mammalian core clock genes.
English
Borgs, Laurence mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Beukelaers, Pierre [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Vandenbosch, Renaud mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Belachew, Shibeshih mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie >]
2009
Cell Cycle (Georgetown, Tex.)
Landes Bioscience
8
6
832-7
Yes (verified by ORBi)
International
1538-4101
1551-4005
Georgetown
TX
[en] Animals ; Biological Clocks/genetics/physiology ; Cell Cycle/genetics/physiology ; Cell Cycle Proteins/genetics/metabolism ; Circadian Rhythm/genetics/physiology ; DNA Damage/genetics/physiology ; Humans ; Signal Transduction/genetics/physiology ; Trans-Activators/genetics/metabolism ; Transcription Factors/genetics/metabolism
[en] In mammals, 24 hours rhythms are organized as a biochemical network of molecular clocks that are operative in all tissues, with the master clock residing in the hypothalamic suprachiasmatic nucleus (SCN). The core pacemakers of these clocks consist of auto-regulatory transcriptional/post-transcriptional feedback loops. Several lines of evidence suggest the existence of a crosstalk between molecules that are responsible for the generation of circadian rhythms and molecules that control the cell cycle progression. In addition, highly specialized cell cycle checkpoints involved in DNA repair after damage seem also, at least in part, mediated by clock proteins. Recent studies have also highlighted a putative connection between clock protein dysfunction and cancer progression. This review discusses the intimate relation that exists between cell cycle progression and components of the circadian machinery.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Fonds Léon Fredericq
http://hdl.handle.net/2268/29790
also: http://hdl.handle.net/2268/78969

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