Reference : Retinoic Acid Stimulates Regeneration of Mammalian Auditory Hair Cells
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Otolaryngology
http://hdl.handle.net/2268/29789
Retinoic Acid Stimulates Regeneration of Mammalian Auditory Hair Cells
English
Lefèbvre, Philippe mailto [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Staecker, H. [> > > >]
Moonen, Gustave mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine]
Van de Water, T. R. [> > > >]
30-Apr-1993
Science
260
5108
692-5
Yes (verified by ORBi)
International
0036-8075
[en] cochlea ; inner ear ; regeneration
[en] Sensorineural hearing loss resulting from the loss of auditory hair cells is thought to be irreversible in mammals. This study provides evidence that retinoic acid can stimulate the regeneration in vitro of mammalian auditory hair cells in ototoxic-poisoned organ of Corti explants in the rat. In contrast, treatment with retinoic acid does not stimulate the formation of extra hair cells in control cultures of Corti's organ. Retinoic acid-stimulated hair cell regeneration can be blocked by cytosine arabinoside, which suggests that a period of mitosis is required for the regeneration of auditory hair cells in this system. These results provide hope for a recovery of hearing function in mammals after auditory hair cell damage.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/29789

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