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Transient hypersensitivity to apomorphine-induced gnawing after termination of acute effects high dose of cocaine
Tirelli, Ezio; Witkin, J. M.
1994In Behavioural Pharmacology, 5 (3), p. 289-298
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Abstract :
[en] Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from brain and the BEs of COC had dissipated (2 hrs and 4 hrs after administration), effects of AP on gnawing were increased 4-fold. This dopaminergic hypersensitivity (DA-H) was induced by acute treatment with doses of 15 mg/kg COC and higher. Effects of AP were not enhanced 6-24 hrs after COC, indicating a rapid waning of the DA-H. Hypersensitivity to AP (AP-H) was not further augmented by 8 days of daily COC injections. COC did not influence climbing and hypomotility induced by AP 4 hrs after its injection, demonstrating selectivity in the BEs of the DA-H. Further, COC did not induce sensitization to its own effects, indicating that the AP-H was not due to a typical sensitization phenomenon. ((c) 1997 APA/PsycINFO, all rights reserved)
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Tirelli, Ezio ;  Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.
Witkin, J. M.
Language :
English
Title :
Transient hypersensitivity to apomorphine-induced gnawing after termination of acute effects high dose of cocaine
Publication date :
1994
Journal title :
Behavioural Pharmacology
ISSN :
0955-8810
eISSN :
1473-5849
Publisher :
Lippincott Williams & Wilkins, London, United Kingdom
Volume :
5
Issue :
3
Pages :
289-298
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 November 2009

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