|Reference : Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant an...|
|Scientific journals : Article|
|Social & behavioral sciences, psychology : Neurosciences & behavior|
|Oxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice|
|Jodogne, C. [> > > >]|
|Tirelli, Ezio [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]|
|Klingbiel, P. [> > > >]|
|Legros, Jean-Jacques [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]|
|Pharmacology, Biochemistry & Behavior|
|Yes (verified by ORBi)|
|[en] Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol.|
|Centre de Neurosciences Cognitives et Comportementales|
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