Reference : Supernumerary outer hair cells arise external to the last row of sensory cells in the or...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Otolaryngology
http://hdl.handle.net/2268/29364
Supernumerary outer hair cells arise external to the last row of sensory cells in the organ of corti.
English
Lefèbvre, Philippe mailto [Université de Liège - ULg > Département des sciences cliniques > Oto-rhino-laryngologie et audiophonologie >]
Malgrange, Brigitte mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. - Neurologie >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Breuskin, Ingrid mailto [Université de Liège - ULg > > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc. >]
Van De Water, T. R. [> > > >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
2001
Acta Oto-Laryngologica
Taylor & Francis
121
2
164-8
Yes (verified by ORBi)
International
0001-6489
Oslo
Norway
[en] Animals ; Cell Count ; Cell Differentiation/physiology ; Female ; Gestational Age ; Hair Cells, Auditory, Inner/cytology ; Hair Cells, Auditory, Outer/cytology ; Organ of Corti/cytology ; Pregnancy ; Rats ; Rats, Wistar
[en] During the development of the mammalian inner ear, the number of hair cells produced is highly regulated and remains constant throughout life. The mechanism underlying this regulation is beginning to be understood although many aspects still remain obscure. When late embryonic or early postnatal rat organs of Corti were cultured, the production of supernumerary hair cells was observed. This overproduction of sensory cells could be modulated by the addition of several growth factors. In this study, we examined explants of rat organs of Corti that produced supernumerary hair cells. In the supernumerary hair cell region, up to two rows of inner hair cells and five rows of outer hair cells were observed. Morphological evaluation of these specimens revealed that less mature hair cells were located in the most external rows of these sensory cells. When a supernumerary hair cell was produced, a supporting cell (i.e. Deiters' cell) was also produced, strongly suggesting that the conversion of a Deiters' cell into a hair cell was not the mechanism that produced these extra hair cells. Based on these results, we propose that prosensory cells located at the external edge of the organ of Corti retain a capacity to form hair cells and that it is these prosensory cells that differentiate into supernumerary hair cells and Deiters' cells.
http://hdl.handle.net/2268/29364
also: http://hdl.handle.net/2268/29445

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
acta otolaryngol (2001) - lefebvre.pdfPublisher postprint352.39 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.